A Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression

PI3K Interacting Protein 1 (PIK3IP1) is a suppressor of the PI3K/Akt/mTOR pathway. We previously reported that activated Ras suppresses PIK3IP1 expression to positively regulate the PI3K pathway in cancer cells. Using doxycycline-inducible PIK3IP1, here we confirm that reversing the effect of Ras by...

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Detalles Bibliográficos
Autores principales: Lee, Kyunghee, Kitagawa, Mayumi, Liao, Pei Ju, Virshup, David M., Lee, Sang Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949251/
https://www.ncbi.nlm.nih.gov/pubmed/31900384
http://dx.doi.org/10.1038/s41389-019-0185-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949251/
https://www.ncbi.nlm.nih.gov/pubmed/31900384
http://dx.doi.org/10.1038/s41389-019-0185-4

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