No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

The No-Go Decay (NGD) mRNA surveillance pathway degrades mRNAs containing stacks of stalled ribosomes. Although an endoribonuclease has been proposed to initiate cleavages upstream of the stall sequence, the production of two RNA fragments resulting from a unique cleavage has never been demonstrated...

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Detalles Bibliográficos
Autores principales: Navickas, Albertas, Chamois, Sébastien, Saint-Fort, Rénette, Henri, Julien, Torchet, Claire, Benard, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949252/
https://www.ncbi.nlm.nih.gov/pubmed/31913314
http://dx.doi.org/10.1038/s41467-019-13991-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949252/
https://www.ncbi.nlm.nih.gov/pubmed/31913314
http://dx.doi.org/10.1038/s41467-019-13991-9

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