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VPS35 regulates tau phosphorylation and neuropathology in tauopathy
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset Alzheimer’s disease. Here we report that VPS35 is signi...
Autores principales: | Vagnozzi, Alana N., Li, Jian-Guo, Chiu, Jin, Razmpour, Roshanak, Warfield, Rebecca, Ramirez, Servio H., Praticò, Domenico |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949432/ https://www.ncbi.nlm.nih.gov/pubmed/31289348 http://dx.doi.org/10.1038/s41380-019-0453-x |
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