Cargando…

VPS35 regulates tau phosphorylation and neuropathology in tauopathy

The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset Alzheimer’s disease. Here we report that VPS35 is signi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vagnozzi, Alana N., Li, Jian-Guo, Chiu, Jin, Razmpour, Roshanak, Warfield, Rebecca, Ramirez, Servio H., Praticò, Domenico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949432/ https://www.ncbi.nlm.nih.gov/pubmed/31289348 http://dx.doi.org/10.1038/s41380-019-0453-x

Ejemplares similares

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
por: Vagnozzi, Alana N., et al.
Publicado: (2017)

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology
por: Wen, Lei, et al.
Publicado: (2011)

Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
por: Vagnozzi, Alana N., et al.
Publicado: (2017)

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2020)

Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration
por: Chen, Xi, et al.
Publicado: (2019)

Acute administration of catalase targeted to ICAM-1 attenuates neuropathology in experimental traumatic brain injury
por: Lutton, Evan M., et al.
Publicado: (2017)

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
por: Li, Jian-Guo, et al.
Publicado: (2020)

Endosomal sorting and trafficking, the retromer complex and neurodegeneration
por: Vagnozzi, Alana N., et al.
Publicado: (2018)

Correction to: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
por: Li, Jian-Guo, et al.
Publicado: (2021)

Extra virgin olive oil improves synaptic activity, short‐term plasticity, memory, and neuropathology in a tauopathy model
por: Lauretti, Elisabetta, et al.
Publicado: (2019)

Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
por: Rawat, Priyanka, et al.
Publicado: (2022)

Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice
por: Giannopoulos, Phillip F., et al.
Publicado: (2018)

The Functional Role of microRNAs in the Pathogenesis of Tauopathy
por: Praticò, Domenico
Publicado: (2020)

Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy
por: Malcolm, Janice C., et al.
Publicado: (2019)

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
por: Bailey, Rachel M., et al.
Publicado: (2013)

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
por: Lauretti, E, et al.
Publicado: (2017)

Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury
por: Andrews, Allison M., et al.
Publicado: (2016)

Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells
por: Gao, Ling, et al.
Publicado: (2020)

Full recovery of the Alzheimer’s disease phenotype by gain of function of Vacuolar Protein Sorting 35
por: Li, Jian-Guo, et al.
Publicado: (2019)

Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau
por: Filippone, Alessia, et al.
Publicado: (2021)

Glucose deprivation increases tau phosphorylation via P38 mitogen‐activated protein kinase
por: Lauretti, Elisabetta, et al.
Publicado: (2015)

Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production
por: Kotredes, Kevin P., et al.
Publicado: (2019)

Transcellular Spreading of Tau in Tauopathies
por: Demaegd, Koen, et al.
Publicado: (2018)

Neuropathological criteria of anti-IgLON5-related tauopathy
por: Gelpi, Ellen, et al.
Publicado: (2016)

Elevated levels of brain homocysteine directly modulates the pathological phenotype of a mouse model of tauopathy
por: Di Meco, Antonio, et al.
Publicado: (2018)

Dexamethasone Attenuates the Enhanced Rewarding Effects of Cocaine Following Experimental Traumatic Brain Injury
por: Merkel, Steven F., et al.
Publicado: (2017)

Are Tau Aggregates Toxic or Protective in Tauopathies?
por: Cowan, Catherine M., et al.
Publicado: (2013)

NMR Studies of Tau Protein in Tauopathies
por: Kitoka, Kristine, et al.
Publicado: (2021)

Threonine(175), a novel pathological phosphorylation site on tau protein linked to multiple tauopathies
por: Moszczynski, Alexander J., et al.
Publicado: (2017)

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
por: Brody, A. Harrison, et al.
Publicado: (2022)

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
por: Smith, Ethan D., et al.
Publicado: (2023)

VPS35 leaves endosomes lost in transition
por: Leslie, Mitch
Publicado: (2011)

Screening for VPS35 mutations in Parkinson's disease
por: Sheerin, Una-Marie, et al.
Publicado: (2012)

VPS35, the Retromer Complex and Parkinson’s Disease
por: Williams, Erin T., et al.
Publicado: (2017)

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2021)

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products
por: Seaman, Matthew N.J., et al.
Publicado: (1997)

Neuropathology of Beta-propeller protein associated neurodegeneration (BPAN): a new tauopathy
por: Paudel, R., et al.
Publicado: (2015)

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation
por: Ambegaokar, Surendra S., et al.
Publicado: (2011)

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies
por: Giacomini, Caterina, et al.
Publicado: (2018)

Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies
por: Pires, Geoffrey, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_stpl7hg5ukv29jttshhqabibvd