Cargando…

Neutrophils suppress tumor‐infiltrating T cells in colon cancer via matrix metalloproteinase‐mediated activation of TGFβ

High T‐cell infiltration in colorectal cancer (CRC) correlates with a favorable disease outcome and immunotherapy response. This, however, is only observed in a small subset of CRC patients. A better understanding of the factors influencing tumor T‐cell responses in CRC could inspire novel therapeut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Germann, Markus, Zangger, Nadine, Sauvain, Marc‐Olivier, Sempoux, Christine, Bowler, Amber D, Wirapati, Pratyaksha, Kandalaft, Lana E, Delorenzi, Mauro, Tejpar, Sabine, Coukos, George, Radtke, Freddy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949488/ https://www.ncbi.nlm.nih.gov/pubmed/31793740 http://dx.doi.org/10.15252/emmm.201910681

Ejemplares similares

Relationship between estrogen receptor α location and gene induction reveals the importance of downstream sites and cofactors
por: Parisi, Fabio, et al.
Publicado: (2009)

Selecting control genes for RT-QPCR using public microarray data
por: Popovici, Vlad, et al.
Publicado: (2009)

Clinical translation section: accelerating the pace from bench to bedside
por: Kandalaft, Lana E, et al.
Publicado: (2011)

Identifying synergistic regulation involving c-Myc and sp1 in human tissues
por: Parisi, Fabio, et al.
Publicado: (2007)

A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6
por: Bengtsson, Henrik, et al.
Publicado: (2009)

A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer
por: Kandalaft, Lana E, et al.
Publicado: (2012)

Whole Tumor Antigen Vaccines: Where Are We?
por: Chiang, Cheryl Lai-Lai, et al.
Publicado: (2015)

Low E2F1 transcript levels are a strong determinant of favorable breast cancer outcome
por: Vuaroqueaux, Vincent, et al.
Publicado: (2007)

Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue
por: Antonov, Janine, et al.
Publicado: (2010)

Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
por: Wirapati, Pratyaksha, et al.
Publicado: (2008)

Guillain-Barré syndrome after adoptive cell therapy with tumor-infiltrating lymphocytes
por: Orcurto, Angela, et al.
Publicado: (2020)

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation
por: Kopparam, Jawahar, et al.
Publicado: (2017)

Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer
por: Popovici, Vlad, et al.
Publicado: (2013)

Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells
por: Groeneveld, Svenja, et al.
Publicado: (2018)

Autologous whole-tumor antigen vaccination in combination with adoptive T cell therapy for patients with recurrent ovarian cancer
por: Kandalaft, Lana E, et al.
Publicado: (2013)

Response to a letter to the editor: a better understanding of Immune Checkpoint Inhibitor-induced cholangitis for better management
por: Coukos, Alexander, et al.
Publicado: (2023)

A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer
por: Kandalaft, Lana E, et al.
Publicado: (2013)

Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma
por: Yakkala, Chakradhar, et al.
Publicado: (2021)

A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma
por: Sarivalasis, Apostolos, et al.
Publicado: (2019)

TEM1-targeting PEGylated PLGA shikonin nanoformulation for immunomodulation and eradication of ovarian cancer
por: Matthaiou, Efthymia-Iliana, et al.
Publicado: (2022)

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer
por: Ramesh, Prashanthi, et al.
Publicado: (2021)

Believe in yourself, and enjoy the ride
por: Kandalaft, Lana E.
Publicado: (2019)

A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma—A Proof of Antigen Discovery Feasibility in Three Patients
por: Bassani-Sternberg, Michal, et al.
Publicado: (2019)

Matrix Metalloproteinases in Cytotoxic Lymphocytes Impact on Tumour Infiltration and Immunomodulation
por: Edsparr, Karin, et al.
Publicado: (2010)

Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity
por: Bassani-Sternberg, Michal, et al.
Publicado: (2017)

Modulation of the peripheral blood transcriptome by the ingestion of probiotic yoghurt and acidified milk in healthy, young men
por: Burton, Kathryn J., et al.
Publicado: (2018)

Vaccines as Priming Tools for T Cell Therapy for Epithelial Cancers
por: Kandalaft, Lana E., et al.
Publicado: (2021)

Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8(+) T cells
por: Mastelic-Gavillet, Beatris, et al.
Publicado: (2019)

Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
por: Facciabene, Andrea, et al.
Publicado: (2012)

Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
por: Duraiswamy, Jaikumar, et al.
Publicado: (2013)

Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and Sequelae
por: Ramírez-Martínez, Gustavo, et al.
Publicado: (2022)

Day-4 Myeloid Dendritic Cells Pulsed with Whole Tumor Lysate Are Highly Immunogenic and Elicit Potent Anti-Tumor Responses
por: Chiang, Cheryl Lai-Lai, et al.
Publicado: (2011)

Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
por: Gahring, Lorise C, et al.
Publicado: (2010)

Methods for Analysis of Matrix Metalloproteinase Regulation of Neutrophil-Endothelial Cell Adhesion
por: Fernandez-Patron, Carlos, et al.
Publicado: (2002)

Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease
por: Wagner, Claudius J., et al.
Publicado: (2016)

Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System – Tuberculosis
por: Poh, Xuan Ying, et al.
Publicado: (2022)

Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis
por: Pham, Hien Thi Thu, et al.
Publicado: (2023)

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas
por: Fennell, Lochlan, et al.
Publicado: (2019)

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen
por: Loi, Sherene, et al.
Publicado: (2008)

Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery
por: Baumgaertner, Petra, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jgsguevdbglf4tr8udt0sav65l