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Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases

Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin family, as a zymogen that is proteolytically a...

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Detalles Bibliográficos
Autores principales: Guevara, Tibisay, Rodriguez-Banqueri, Arturo, Ksiazek, Miroslaw, Potempa, Jan, Gomis-Rüth, F. Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949598/
https://www.ncbi.nlm.nih.gov/pubmed/31949901
http://dx.doi.org/10.1107/S2052252519013848