Toxicity, Pharmacokinetics, and Gut Microbiome of Oral Administration of Sesterterpene MHO7 Derived from a Marine Fungus

Sesterterpene MHO7 derived from mangrove fungus is a novel estrogen receptor degrader for the treatment of breast cancer. To explore its safety and pharmacokinetics in vivo, Log P/D values, stability in simulated gastric/intestinal (SGF/SIF), toxicity, and pharmacokinetics studies were carried mainl...

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Detalles Bibliográficos
Autores principales: Tian, Wei, Yang, Liang, Wu, Di, Deng, Zixin, Hong, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950057/
https://www.ncbi.nlm.nih.gov/pubmed/31779201
http://dx.doi.org/10.3390/md17120667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950057/
https://www.ncbi.nlm.nih.gov/pubmed/31779201
http://dx.doi.org/10.3390/md17120667

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