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Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging

The microbiota–gut–brain axis has attracted increasing attention in the last decade. Here, we investigated whether okara, a soybean by-product rich in dietary fiber, can attenuate cognitive impairment in senescence-accelerated mouse prone 8 (SAMP8) mice by altering gut microbial composition. Mice we...

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Autores principales: Corpuz, Henry M., Arimura, Misa, Chawalitpong, Supatta, Miyazaki, Keiko, Sawaguchi, Makoto, Nakamura, Soichiro, Katayama, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950093/
https://www.ncbi.nlm.nih.gov/pubmed/31816987
http://dx.doi.org/10.3390/nu11122939
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author Corpuz, Henry M.
Arimura, Misa
Chawalitpong, Supatta
Miyazaki, Keiko
Sawaguchi, Makoto
Nakamura, Soichiro
Katayama, Shigeru
author_facet Corpuz, Henry M.
Arimura, Misa
Chawalitpong, Supatta
Miyazaki, Keiko
Sawaguchi, Makoto
Nakamura, Soichiro
Katayama, Shigeru
author_sort Corpuz, Henry M.
collection PubMed
description The microbiota–gut–brain axis has attracted increasing attention in the last decade. Here, we investigated whether okara, a soybean by-product rich in dietary fiber, can attenuate cognitive impairment in senescence-accelerated mouse prone 8 (SAMP8) mice by altering gut microbial composition. Mice were fed either a standard diet, or a diet containing okara (7.5% or 15%, w/w) for 26 weeks. In the memory test, the 7.5% okara-fed mice showed a longer step-through latency and the 15% okara-fed mice had a short escape latency compared with control mice. The 15% okara-fed mice displayed decreased body weight, increased fecal weight, and altered cecal microbiota composition compared with the control group; however, there was no significant difference in the serum lactic acid and butyric acid levels among these mice groups. The 7.5% okara-fed mice had significantly higher NeuN intensity in the hippocampus compared with control mice. Furthermore, a decrease in inflammatory cytokine TNF-α and an increase in brain-derived neurotrophic factor (BDNF) was observed in the 7.5% okara-fed group. The expression of synthesizing enzyme of acetylcholine was increased by the okara diets, and the acetylcholine level in the brain was higher in the 7.5% okara-fed group than in the control. These suggest that oral administration of okara could delay cognitive decline without drastically changing gut microbiota.
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spelling pubmed-69500932020-01-13 Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging Corpuz, Henry M. Arimura, Misa Chawalitpong, Supatta Miyazaki, Keiko Sawaguchi, Makoto Nakamura, Soichiro Katayama, Shigeru Nutrients Article The microbiota–gut–brain axis has attracted increasing attention in the last decade. Here, we investigated whether okara, a soybean by-product rich in dietary fiber, can attenuate cognitive impairment in senescence-accelerated mouse prone 8 (SAMP8) mice by altering gut microbial composition. Mice were fed either a standard diet, or a diet containing okara (7.5% or 15%, w/w) for 26 weeks. In the memory test, the 7.5% okara-fed mice showed a longer step-through latency and the 15% okara-fed mice had a short escape latency compared with control mice. The 15% okara-fed mice displayed decreased body weight, increased fecal weight, and altered cecal microbiota composition compared with the control group; however, there was no significant difference in the serum lactic acid and butyric acid levels among these mice groups. The 7.5% okara-fed mice had significantly higher NeuN intensity in the hippocampus compared with control mice. Furthermore, a decrease in inflammatory cytokine TNF-α and an increase in brain-derived neurotrophic factor (BDNF) was observed in the 7.5% okara-fed group. The expression of synthesizing enzyme of acetylcholine was increased by the okara diets, and the acetylcholine level in the brain was higher in the 7.5% okara-fed group than in the control. These suggest that oral administration of okara could delay cognitive decline without drastically changing gut microbiota. MDPI 2019-12-03 /pmc/articles/PMC6950093/ /pubmed/31816987 http://dx.doi.org/10.3390/nu11122939 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corpuz, Henry M.
Arimura, Misa
Chawalitpong, Supatta
Miyazaki, Keiko
Sawaguchi, Makoto
Nakamura, Soichiro
Katayama, Shigeru
Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging
title Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging
title_full Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging
title_fullStr Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging
title_full_unstemmed Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging
title_short Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging
title_sort oral administration of okara soybean by-product attenuates cognitive impairment in a mouse model of accelerated aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950093/
https://www.ncbi.nlm.nih.gov/pubmed/31816987
http://dx.doi.org/10.3390/nu11122939
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