Evaluation of Marine Diindolinonepyrane in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetic Properties in Beagle Dogs

A marine fibrinolytic compound was studied for use in thrombolytic therapy. Firstly, the absorption and transportation characteristics of 2,5-BHPA (2,5-BHPA:2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-tertahydro-6H-pyran[a]isoindol-2-yl]-pentanoic acid, a novel py...

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Detalles Bibliográficos
Autores principales: Ma, Zibin, Guo, Ruihua, Elango, Jeevithan, Bao, Bin, Wu, Wenhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950567/
https://www.ncbi.nlm.nih.gov/pubmed/31757085
http://dx.doi.org/10.3390/md17120651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950567/
https://www.ncbi.nlm.nih.gov/pubmed/31757085
http://dx.doi.org/10.3390/md17120651

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