Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors

KTM is a 16 amino acid peptide with the sequence WCCSYPGCYWSSSKWC. Here, we present the nuclear magnetic resonance (NMR) structure and bioactivity of this rationally designed α-conotoxin (α-CTx) that demonstrates potent inhibition of rat α3β2-nicotinic acetylcholine receptors (rα3β2-nAChRs). Two bio...

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Detalles Bibliográficos
Autores principales: Marquart, Leanna A., Turner, Matthew W., Warner, Lisa R., King, Matthew D., Groome, James R., McDougal, Owen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950571/
https://www.ncbi.nlm.nih.gov/pubmed/31795126
http://dx.doi.org/10.3390/md17120669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950571/
https://www.ncbi.nlm.nih.gov/pubmed/31795126
http://dx.doi.org/10.3390/md17120669

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