A Natural Quinazoline Derivative from Marine Sponge Hyrtios erectus Induces Apoptosis of Breast Cancer Cells via ROS Production and Intrinsic or Extrinsic Apoptosis Pathways

Here, we report the therapeutic potential of a natural quinazoline derivative (2-chloro-6-phenyl-8H-quinazolino[4,3-b]quinazolin-8-one) isolated from marine sponge Hyrtios erectus against human breast cancer. The cytotoxicity of the compound was investigated on a human breast carcinoma cell line (MC...

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Detalles Bibliográficos
Autores principales: De, Arun Kumar, Muthiyan, Ramachandran, Mondal, Samiran, Mahanta, Nilkamal, Bhattacharya, Debasis, Ponraj, Perumal, Muniswamy, Kangayan, Kundu, Anandamoy, Kundu, Madhu Sudhan, Sunder, Jai, Karunakaran, Dhanasekar, Bera, Asit Kumar, Roy, Sibnarayan Dam, Malakar, Dhruba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950652/
https://www.ncbi.nlm.nih.gov/pubmed/31771152
http://dx.doi.org/10.3390/md17120658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950652/
https://www.ncbi.nlm.nih.gov/pubmed/31771152
http://dx.doi.org/10.3390/md17120658

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