Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis

BACKGROUND: The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribine, and mitoxantrone, across cell membranes and organelles....

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Detalles Bibliográficos
Autores principales: Thiele née Schrewe, Lisa, Guse, Kirsten, Tietz, Silvia, Remlinger, Jana, Demir, Seray, Pedreiturria, Xiomara, Hoepner, Robert, Salmen, Anke, Pistor, Maximilian, Turner, Timothy, Engelhardt, Britta, Hermann, Dirk M., Lühder, Fred, Wiese, Stefan, Chan, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951012/
https://www.ncbi.nlm.nih.gov/pubmed/31915017
http://dx.doi.org/10.1186/s12974-019-1677-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951012/
https://www.ncbi.nlm.nih.gov/pubmed/31915017
http://dx.doi.org/10.1186/s12974-019-1677-z

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