miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

BACKGROUND: Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐COX1. miR‐181c/d(−/−) hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Additionally, miR‐181c overexpression can increase mitochondr...

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Detalles Bibliográficos
Autores principales: Banavath, Hemanth N., Roman, Barbara, Mackowski, Nathan, Biswas, Debjit, Afzal, Junaid, Nomura, Yohei, Solhjoo, Soroosh, O'Rourke, Brian, Kohr, Mark, Murphy, Elizabeth, Steenbergen, Charles, Das, Samarjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951067/
https://www.ncbi.nlm.nih.gov/pubmed/31801413
http://dx.doi.org/10.1161/JAHA.119.012919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951067/
https://www.ncbi.nlm.nih.gov/pubmed/31801413
http://dx.doi.org/10.1161/JAHA.119.012919

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