Cargando…

miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

BACKGROUND: Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐COX1. miR‐181c/d(−/−) hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Additionally, miR‐181c overexpression can increase mitochondr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Banavath, Hemanth N., Roman, Barbara, Mackowski, Nathan, Biswas, Debjit, Afzal, Junaid, Nomura, Yohei, Solhjoo, Soroosh, O'Rourke, Brian, Kohr, Mark, Murphy, Elizabeth, Steenbergen, Charles, Das, Samarjit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951067/ https://www.ncbi.nlm.nih.gov/pubmed/31801413 http://dx.doi.org/10.1161/JAHA.119.012919

Ejemplares similares

miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling
por: Hori, Daijiro, et al.
Publicado: (2017)

Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability
por: Solhjoo, Soroosh, et al.
Publicado: (2022)

Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca(2+) uptake
por: Ashok, Deepthi, et al.
Publicado: (2023)

Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients
por: Singh, Raghavendra, et al.
Publicado: (2022)

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling
por: Plovanich, Molly, et al.
Publicado: (2013)

Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts
por: Shao, Qin, et al.
Publicado: (2017)

Divergent Effects of miR‐181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets
por: Das, Samarjit, et al.
Publicado: (2017)

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca(2+) Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi
por: Bertolini, Mayara S., et al.
Publicado: (2019)

The Function of Mitochondrial Calcium Uniporter at the Whole-Cell and Single Mitochondrion Levels in WT, MICU1 KO, and MICU2 KO Cells
por: Shah, Syed Islamuddin, et al.
Publicado: (2020)

Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors
por: Bertolini, Mayara S., et al.
Publicado: (2020)

MICU1-dependent mitochondrial calcium uptake regulates lung alveolar type 2 cell plasticity and lung regeneration
por: Ali, Mir, et al.
Publicado: (2022)

SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND SKELETAL MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO
por: Li, Xuexin, et al.
Publicado: (2023)

Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics()
por: Bhosale, Gauri, et al.
Publicado: (2017)

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion
por: Vishnu, N., et al.
Publicado: (2021)

MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions
por: Rodríguez-Prados, Macarena, et al.
Publicado: (2023)

Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes
por: Lan, Tianyang, et al.
Publicado: (2022)

Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2
por: Wang, Chongyuan, et al.
Publicado: (2020)

Structure of the MICU1–MICU2 heterodimer provides insights into the gatekeeping threshold shift
por: Park, Jongseo, et al.
Publicado: (2020)

miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo
por: Das, Samarjit, et al.
Publicado: (2014)

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration
por: Antony, Anil Noronha, et al.
Publicado: (2016)

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter
por: Bick, Alexander G., et al.
Publicado: (2017)

Mitochondrial Calcium Uptake 1 (MICU1) Gene-Related Myopathy with Extrapyramidal Signs: A Clinico-Radiological Case Report from India
por: Mukherjee, Debaleena, et al.
Publicado: (2023)

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
por: Perocchi, Fabiana, et al.
Publicado: (2010)

MICU1 and MICU2 Finely Tune the Mitochondrial Ca(2+) Uniporter by Exerting Opposite Effects on MCU Activity
por: Patron, Maria, et al.
Publicado: (2014)

Glyceraldehyde-3-Phosphate Dehydrogenase Acts as a Mitochondrial Trans-S-Nitrosylase in the Heart
por: Kohr, Mark J., et al.
Publicado: (2014)

Expression and preliminary characterization of human MICU2
por: Li, Dan, et al.
Publicado: (2016)

MICU1- Related Myopathy with Extrapyramidal Signs
por: Mukherjee, Debaleena, et al.
Publicado: (2023)

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
por: Phillips, Charles B, et al.
Publicado: (2019)

Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex
por: Tsai, Chen-Wei, et al.
Publicado: (2023)

An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile
por: Gutiérrez-Mireles, Emilia R., et al.
Publicado: (2023)

MICU1 drives glycolysis and chemoresistance in ovarian cancer
por: Chakraborty, Prabir K., et al.
Publicado: (2017)

Role of miR-181c in Diet-induced obesity through regulation of lipid synthesis in liver
por: Akiyoshi, Kei, et al.
Publicado: (2021)

Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1
por: Debattisti, Valentina, et al.
Publicado: (2019)

Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood
por: Lewis-Smith, David, et al.
Publicado: (2016)

Parkin-dependent regulation of the MCU complex component MICU1
por: Matteucci, Alessandra, et al.
Publicado: (2018)

Structure of intact human MCU supercomplex with the auxiliary MICU subunits
por: Zhuo, Wei, et al.
Publicado: (2020)

The mechanism of MICU-dependent gating of the mitochondrial Ca(2+)uniporter
por: Garg, Vivek, et al.
Publicado: (2021)

Autosomal Recessive Mitochondrial Myopathy due to MICU-1 Variants
por: Finsterer, Josef
Publicado: (2023)

The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation
por: Vecellio Reane, Denis, et al.
Publicado: (2022)

Adenosine A(2A) Receptor Regulates microRNA‐181b Expression in Aorta: Therapeutic Implications for Large‐Artery Stiffness
por: Akiyoshi, Kei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8t8t2qv7v3e4kqnagkaftjuega