Temperature and eluent composition effects on enantiomer separation of carvedilol by high-performance liquid chromatography on immobilized amylose-based chiral stationary phases

Carvedilol is a chiral drug with potent antihypertensive and antianginal activities. Although it is clinically used as a racemic mixture, its enantiomers show different pharmacokinetic and pharmacodynamic profiles. Here, the direct chiral separation of racemic drug by high performance liquid chromat...

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Detalles Bibliográficos
Autores principales: Panella, Cristina, Ferretti, Rosella, Casulli, Adriano, Cirilli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951491/
https://www.ncbi.nlm.nih.gov/pubmed/31929941
http://dx.doi.org/10.1016/j.jpha.2019.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951491/
https://www.ncbi.nlm.nih.gov/pubmed/31929941
http://dx.doi.org/10.1016/j.jpha.2019.04.002

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