Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved when diplotype assignments incorporate structural var...

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Detalles Bibliográficos
Autores principales: Dalton, Rachel, Lee, Seung‐been, Claw, Katrina G., Prasad, Bhagwat, Phillips, Brian R., Shen, Danny D., Wong, Lai Hong, Fade, Mitch, McDonald, Matthew G., Dunham, Maitreya J., Fowler, Douglas M., Rettie, Allan E., Schuetz, Erin, Thornton, Timothy A., Nickerson, Deborah A., Gaedigk, Andrea, Thummel, Kenneth E., Woodahl, Erica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951848/
https://www.ncbi.nlm.nih.gov/pubmed/31536170
http://dx.doi.org/10.1111/cts.12695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951848/
https://www.ncbi.nlm.nih.gov/pubmed/31536170
http://dx.doi.org/10.1111/cts.12695

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