MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Sdelci, Sara, Rendeiro, André F., Rathert, Philipp, You, Wanhui, Lin, Jung-Ming G., Ringler, Anna, Hofstätter, Gerald, Moll, Herwig P., Gürtl, Bettina, Farlik, Matthias, Schick, Sandra, Klepsch, Freya, Oldach, Matthew, Buphamalai, Pisanu, Schischlik, Fiorella, Májek, Peter, Parapatics, Katja, Schmidl, Christian, Schuster, Michael, Penz, Thomas, Buckley, Dennis L., Hudecz, Otto, Imre, Richard, Wang, Shuang-Yan, Maric, Hans Michael, Kralovics, Robert, Bennett, Keiryn L., Müller, Andre C., Mechtler, Karl, Menche, Jörg, Bradner, James E., Winter, Georg E., Klavins, Kristaps, Casanova, Emilio, Bock, Christoph, Zuber, Johannes, Kubicek, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952269/
https://www.ncbi.nlm.nih.gov/pubmed/31133746
http://dx.doi.org/10.1038/s41588-019-0413-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952269/
https://www.ncbi.nlm.nih.gov/pubmed/31133746
http://dx.doi.org/10.1038/s41588-019-0413-z

Ejemplares similares