Systematic characterization of BAF mutations provides insights into intra-complex synthetic lethalities in human cancers

Aberrations in genes coding for subunits of the BAF chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not understood how these loss-of-function mutations contribute to cancer development and how they can be targeted therapeutically. The cancer-type-specific occurr...

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Detalles Bibliográficos
Autores principales: Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Mueller, André C., Bock, Christoph, Kubicek, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952272/
https://www.ncbi.nlm.nih.gov/pubmed/31427792
http://dx.doi.org/10.1038/s41588-019-0477-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952272/
https://www.ncbi.nlm.nih.gov/pubmed/31427792
http://dx.doi.org/10.1038/s41588-019-0477-9

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