Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling

Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical biophysical role in cancer progression, but the precise pro-metastatic mechanisms are not clear. Activin A, a TGF-β...

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Detalles Bibliográficos
Autores principales: Bauer, Jessica, Emon, Md Abdul Bashar, Staudacher, Jonas J., Thomas, Alexandra L., Zessner-Spitzenberg, Jasmin, Mancinelli, Georgina, Krett, Nancy, Saif, M. Taher, Jung, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952350/
https://www.ncbi.nlm.nih.gov/pubmed/31919369
http://dx.doi.org/10.1038/s41598-019-55687-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952350/
https://www.ncbi.nlm.nih.gov/pubmed/31919369
http://dx.doi.org/10.1038/s41598-019-55687-6

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