Structure-activity relationship studies of four novel 4-aminopyridine K(+) channel blockers

4-Aminopyridine (4AP) is a specific blocker of voltage-gated potassium channels (K(V)1 family) clinically approved for the symptomatic treatment of patients with multiple sclerosis (MS). It has recently been shown that [(18)F]3F4AP, a radiofluorinated analog of 4AP, also binds to K(V)1 channels and...

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Detalles Bibliográficos
Autores principales: Rodríguez-Rangel, Sofia, Bravin, Alyssa D., Ramos-Torres, Karla M., Brugarolas, Pedro, Sánchez-Rodríguez, Jorge E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952366/
https://www.ncbi.nlm.nih.gov/pubmed/31919372
http://dx.doi.org/10.1038/s41598-019-56245-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952366/
https://www.ncbi.nlm.nih.gov/pubmed/31919372
http://dx.doi.org/10.1038/s41598-019-56245-w

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