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Structure-activity relationship studies of four novel 4-aminopyridine K(+) channel blockers
4-Aminopyridine (4AP) is a specific blocker of voltage-gated potassium channels (K(V)1 family) clinically approved for the symptomatic treatment of patients with multiple sclerosis (MS). It has recently been shown that [(18)F]3F4AP, a radiofluorinated analog of 4AP, also binds to K(V)1 channels and...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952366/ https://www.ncbi.nlm.nih.gov/pubmed/31919372 http://dx.doi.org/10.1038/s41598-019-56245-w |