A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2(−/−) phenotype

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage renal failure in humans and results from germline mutations in PKD1 or PKD2. Despite the recent approval of tolvaptan, safer and more effective alternative drugs are clearly needed to slow disease pr...

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Detalles Bibliográficos
Autores principales: Metzner, A., Griffiths, J. D., Streets, A. J., Markham, E., Philippou, T., Van Eeden, F. J. M., Ong, A. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952374/
https://www.ncbi.nlm.nih.gov/pubmed/31919453
http://dx.doi.org/10.1038/s41598-019-56995-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952374/
https://www.ncbi.nlm.nih.gov/pubmed/31919453
http://dx.doi.org/10.1038/s41598-019-56995-7

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