Structural basis for itraconazole-mediated NPC1 inhibition

Niemann-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes. TMs 3–7 of NPC1 comprise the Sterol-Sensing Domain (SSD). Previous studies suggest that mutation of the NPC1-SSD or the a...

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Detalles Bibliográficos
Autores principales: Long, Tao, Qi, Xiaofeng, Hassan, Abdirahman, Liang, Qiren, De Brabander, Jef K., Li, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952396/
https://www.ncbi.nlm.nih.gov/pubmed/31919352
http://dx.doi.org/10.1038/s41467-019-13917-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952396/
https://www.ncbi.nlm.nih.gov/pubmed/31919352
http://dx.doi.org/10.1038/s41467-019-13917-5

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