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Interferon mediated neuroinflammation in polyglutamine disease is not caused by RNA toxicity
Polyglutamine diseases are neurodegenerative diseases that occur due to the expansion of CAG repeat regions in coding sequences of genes. Previously, we have shown the formation of large protein aggregates along with activation of the interferon pathway leading to apoptosis in a cellular model of SC...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952400/ https://www.ncbi.nlm.nih.gov/pubmed/31919387 http://dx.doi.org/10.1038/s41419-019-2193-x |