Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos

Deaminase base editing has emerged as a tool to install or correct point mutations in the genomes of living cells in a wide range of organisms. However, the genome-wide off-target effects introduced by base editors in the mammalian genome have been examined in only one study. Here, we have investiga...

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Detalles Bibliográficos
Autores principales: Lee, Hye Kyung, Smith, Harold E., Liu, Chengyu, Willi, Michaela, Hennighausen, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952419/
https://www.ncbi.nlm.nih.gov/pubmed/31925293
http://dx.doi.org/10.1038/s42003-019-0745-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952419/
https://www.ncbi.nlm.nih.gov/pubmed/31925293
http://dx.doi.org/10.1038/s42003-019-0745-3

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