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Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
Deaminase base editing has emerged as a tool to install or correct point mutations in the genomes of living cells in a wide range of organisms. However, the genome-wide off-target effects introduced by base editors in the mammalian genome have been examined in only one study. Here, we have investiga...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952419/ https://www.ncbi.nlm.nih.gov/pubmed/31925293 http://dx.doi.org/10.1038/s42003-019-0745-3 |