GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

Dysregulated hematopoiesis occurs in several chronic inflammatory diseases, but it remains unclear how hematopoietic stem cells (HSCs) in the bone marrow (BM) sense peripheral inflammation and contribute to tissue damage in arthritis. Here, we show the HSC gene expression program is biased toward my...

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Detalles Bibliográficos
Autores principales: Regan-Komito, Daniel, Swann, James W., Demetriou, Philippos, Cohen, E. Suzanne, Horwood, Nicole J., Sansom, Stephen N., Griseri, Thibault
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952438/
https://www.ncbi.nlm.nih.gov/pubmed/31919358
http://dx.doi.org/10.1038/s41467-019-13853-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952438/
https://www.ncbi.nlm.nih.gov/pubmed/31919358
http://dx.doi.org/10.1038/s41467-019-13853-4

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