Cargando…

GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

Dysregulated hematopoiesis occurs in several chronic inflammatory diseases, but it remains unclear how hematopoietic stem cells (HSCs) in the bone marrow (BM) sense peripheral inflammation and contribute to tissue damage in arthritis. Here, we show the HSC gene expression program is biased toward my...

Descripción completa

Detalles Bibliográficos
Autores principales:	Regan-Komito, Daniel, Swann, James W., Demetriou, Philippos, Cohen, E. Suzanne, Horwood, Nicole J., Sansom, Stephen N., Griseri, Thibault
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952438/ https://www.ncbi.nlm.nih.gov/pubmed/31919358 http://dx.doi.org/10.1038/s41467-019-13853-4

Ejemplares similares

IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors
por: Swann, James W., et al.
Publicado: (2020)

G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
por: He, Kai, et al.
Publicado: (2022)

GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity
por: Ruffolo, Luis I, et al.
Publicado: (2022)

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
por: Al-Mossawi, M. H., et al.
Publicado: (2017)

ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation
por: Pearson, Claire, et al.
Publicado: (2016)

Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation
por: Griseri, Thibault, et al.
Publicado: (2012)

Extramedullary hematopoiesis: mesenchymal stromal cells from spleen provide an in vitro niche for myelopoiesis
por: Petvises, Sawang, et al.
Publicado: (2022)

Extramedullary Myelopoiesis in Malaria Depends on Mobilization of Myeloid-Restricted Progenitors by IFN-γ Induced Chemokines
por: Belyaev, Nikolai N., et al.
Publicado: (2013)

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells
por: Singer, Kanakadurga, et al.
Publicado: (2014)

GM-CSF in inflammation
por: Hamilton, John A.
Publicado: (2019)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

Transient abnormal myelopoiesis with extramedullary involvement in a down syndrome preemie leading to an unresponsive course despite chemotherapy
por: Geetha, Saroja Devi, et al.
Publicado: (2023)

Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders
por: Lazarus, Hillard M., et al.
Publicado: (2023)

Sclerosing Extramedullary Hematopoietic Tumor
por: Deniz, Kemal, et al.
Publicado: (2018)

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF–mediated myelopoiesis
por: Karmaus, Peer W.F., et al.
Publicado: (2017)

PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen
por: Liu, Mingyu, et al.
Publicado: (2022)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

GM-CSF-Dependent Inflammatory Pathways
por: Hamilton, John A.
Publicado: (2019)

Development of Dendritic Cells from GM-CSF(-/-) Mice in vitro : GM-CSF Enhances Production and Survival of Cells
por: Ni, Keping, et al.
Publicado: (2001)

Loss and gain of bone in spondyloarthritis: what drives these opposing clinical features?
por: Clunie, Gavin, et al.
Publicado: (2020)

Novel role of interleukin 7 in myelopoiesis: stimulation of primitive murine hematopoietic progenitor cells
Publicado: (1993)

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity
por: Khan, Nargis, et al.
Publicado: (2020)

Correction: PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen
por: Liu, Mingyu, et al.
Publicado: (2022)

Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF(+) T Lymphocytes
por: Bystrom, Jonas, et al.
Publicado: (2017)

Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity
por: Pykhtina, Mariya, et al.
Publicado: (2021)

GM-CSF Programs Hematopoietic Stem and Progenitor Cells During Candida albicans Vaccination for Protection Against Reinfection
por: Bono, Cristina, et al.
Publicado: (2021)

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
por: Shiomi, Aoi, et al.
Publicado: (2015)

A Review of GM-CSF Therapy in Sepsis
por: Mathias, Brittany, et al.
Publicado: (2015)

The efficacy and safety of targeting GM-CSF in arthritis
por: Bykerk, Vivian P
Publicado: (2020)

GM-CSF: Orchestrating the Pulmonary Response to Infection
por: McCormick, Thomas S., et al.
Publicado: (2022)

Role of GM-CSF in lung balance and disease
por: Chen, Yingzi, et al.
Publicado: (2023)

Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue
por: Hou, Yuelan, et al.
Publicado: (2016)

Myelopoiesis of the Amphibian Xenopus laevis Is Segregated to the Bone Marrow, Away From Their Hematopoietic Peripheral Liver
por: Yaparla, Amulya, et al.
Publicado: (2020)

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment
por: Bosteels, Cedric, et al.
Publicado: (2022)

Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish
por: Forrester, A. Michael, et al.
Publicado: (2012)

Serum granulocyte-macrophage colony-stimulating factor (GM-CSF) is increased in patients with active radiographic axial spondyloarthritis and persists despite anti-TNF treatment
por: Papagoras, Charalampos, et al.
Publicado: (2022)

Myeloid progenitor cluster formation drives emergency and leukemic myelopoiesis
por: Hérault, Aurélie, et al.
Publicado: (2017)

Retroperitoneal extramedullary hematopoietic pseudotumor in ataxia–telangiectasia
por: Judge, Sean James, et al.
Publicado: (2018)

Extramedullary hematopoietic pleural effusion in Waldenström's macroglobulinemia
por: Ito, Kenichi, et al.
Publicado: (2023)

Neutrophil GM‐CSF receptor dynamics in acute lung injury
por: De Alessandris, Silvia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7e126vcu835nli1iuaajn6csjd