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T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions

The spontaneous contractions of collecting lymphatic vessels provide an essential propulsive force to return lymph centrally. These contractions are driven by an intrinsic electrical pacemaker, working through an unknown underlying ionic mechanism that becomes compromised in some forms of lymphedema...

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Detalles Bibliográficos
Autores principales: To, Kim H. T., Gui, Peichun, Li, Min, Zawieja, Scott D., Castorena-Gonzalez, Jorge A., Davis, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952455/
https://www.ncbi.nlm.nih.gov/pubmed/31919478
http://dx.doi.org/10.1038/s41598-019-56953-3