Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function

The tumour suppressor PTEN is frequently downregulated, mutated or lost in several types of tumours and congenital disorders including PHTS (PTEN Hamartoma Tumour Syndrome) and ASD (Autism Spectrum Disorder). PTEN is a lipid phosphatase whose activity over the lipid messenger PIP(3) counteracts the...

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Detalles Bibliográficos
Autores principales: Fernández-Acero, Teresa, Bertalmio, Eleonora, Luna, Sandra, Mingo, Janire, Bravo-Plaza, Ignacio, Rodríguez-Escudero, Isabel, Molina, María, Pulido, Rafael, Cid, Víctor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952770/
https://www.ncbi.nlm.nih.gov/pubmed/31779149
http://dx.doi.org/10.3390/cells8121512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952770/
https://www.ncbi.nlm.nih.gov/pubmed/31779149
http://dx.doi.org/10.3390/cells8121512

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