Cargando…

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Transforming growth factor-β (TGFβ) has both tumor-suppressive and tumor-promoting effects in breast cancer. These functions are partly mediated through Smads, intracellular transcriptional effectors of TGFβ. Smads form complexes with other DNA-binding transcription factors to elicit cell-type-depen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sundqvist, Anders, Voytyuk, Oleksandr, Hamdi, Mohamed, Popeijus, Herman E., Bijlsma-van der Burgt, Corina, Janssen, Josephine, Martens, John W.M., Moustakas, Aristidis, Heldin, Carl-Henrik, ten Dijke, Peter, van Dam, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952832/ https://www.ncbi.nlm.nih.gov/pubmed/31766464 http://dx.doi.org/10.3390/cells8121481

Ejemplares similares

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness
por: Sundqvist, Anders, et al.
Publicado: (2020)

Selection and Characterization of a DNA Aptamer That Can Discriminate between cJun/cJun and cJun/cFos
por: Walters, Ryan D., et al.
Publicado: (2014)

Selective antagonism of cJun for cancer therapy
por: Brennan, Andrew, et al.
Publicado: (2020)

cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
por: Khalid, Sana, et al.
Publicado: (2016)

The cJUN NH(2)-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation
por: Girnius, Nomeda, et al.
Publicado: (2018)

The cJUN NH(2)-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution
por: Girnius, Nomeda, et al.
Publicado: (2018)

p27 transcriptionally coregulates cJun to drive programs of tumor progression
por: Yoon, Hyunho, et al.
Publicado: (2019)

RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation
por: Song, Li-Jun, et al.
Publicado: (2022)

Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant
por: Shimizu, Y, et al.
Publicado: (2008)

Platinum-Resistant Ovarian Cancer Is Vulnerable to the cJUN-XRCC4 Pathway Inhibition
por: Xu, Manman, et al.
Publicado: (2022)

In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun
por: Leech, James T., et al.
Publicado: (2022)

cJun phosphorylation integrates calcium spike activity and tlx3 expression to regulate neurotransmitter specification
por: Marek, Kurt W., et al.
Publicado: (2010)

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
por: Kim, Byung-Jin, et al.
Publicado: (2016)

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
por: Schattauer, Selena S., et al.
Publicado: (2017)

Role of the MAPK/cJun NH(2)-terminal kinase signaling pathway in starvation-induced autophagy
por: Barutcu, Seda Avcioglu, et al.
Publicado: (2018)

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte
por: Udden, SM Nashir, et al.
Publicado: (2019)

The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist
por: Brennan, Andrew, et al.
Publicado: (2022)

Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway
por: Lin, Yi-Hsuan, et al.
Publicado: (2020)

The Role of Reduced Oxygen Supply and Transcription Factors cJUN and CREB in Progesterone Production during the Corpus Luteum Rescue in Gilts
por: Przygrodzka, Emilia, et al.
Publicado: (2022)

CD44v6+ Hepatocellular Carcinoma Cells Maintain Stemness Properties through Met/cJun/Nanog Signaling
por: Chen, Wei, et al.
Publicado: (2022)

Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death
por: Brandt, B, et al.
Publicado: (2010)

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition
por: Moustakas, Aristidis, et al.
Publicado: (2016)

Excitatory transmission onto AgRP neurons is regulated by cJun NH(2)-terminal kinase 3 in response to metabolic stress
por: Vernia, Santiago, et al.
Publicado: (2016)

Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation
por: Zhan, Hongrui, et al.
Publicado: (2020)

Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularization
por: Kumar, Raj, et al.
Publicado: (2016)

Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis
por: Christensen, Dan Ploug, et al.
Publicado: (2016)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cells
por: Maturi, Varun, et al.
Publicado: (2018)

Regulation of Jun and Fos AP-1 transcription factors by JNK MAPKs signaling cascade in areca nut extract treated KB cells
por: Nagesh, Rashmi, et al.
Publicado: (2021)

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
por: Kolliopoulos, Constantinos, et al.
Publicado: (2019)

Interleukin-33 induces interleukin-8 expression via JNK/c-Jun/AP-1 pathway in human umbilical vein endothelial cells
por: Umebashi, Katsuyuki, et al.
Publicado: (2018)

Notch signaling is necessary for epithelial growth arrest by TGF-β
por: Niimi, Hideki, et al.
Publicado: (2007)

Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells
por: Maturi, Varun, et al.
Publicado: (2018)

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer
por: Ruiz, E. Josue, et al.
Publicado: (2021)

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
por: Raja, Erna, et al.
Publicado: (2015)

Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
por: Tsirigoti, Chrysoula, et al.
Publicado: (2022)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

TGFβ induces SIK to negatively regulate type I receptor kinase signaling
por: Kowanetz, Marcin, et al.
Publicado: (2008)

Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition
por: Thuault, Sylvie, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_rdojsvdm66vrlcun2lv42a1829