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Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [(18)F]FAZA PET In Vivo
Tumors lack a well-regulated vascular supply of O(2) and often fail to balance O(2) supply and demand. Net O(2) tension within many tumors may not only depend on O(2) delivery but also depend strongly on O(2) demand. Thus, tumor O(2) consumption rates may influence tumor hypoxia up to true anoxia. R...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952969/ https://www.ncbi.nlm.nih.gov/pubmed/31766580 http://dx.doi.org/10.3390/cells8121487 |