Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [(18)F]FAZA PET In Vivo

Tumors lack a well-regulated vascular supply of O(2) and often fail to balance O(2) supply and demand. Net O(2) tension within many tumors may not only depend on O(2) delivery but also depend strongly on O(2) demand. Thus, tumor O(2) consumption rates may influence tumor hypoxia up to true anoxia. R...

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Detalles Bibliográficos
Autores principales: Gammon, Seth T., Pisaneschi, Federica, Bandi, Madhavi L., Smith, Melinda G., Sun, Yuting, Rao, Yi, Muller, Florian, Wong, Franklin, De Groot, John, Ackroyd, Jeffrey, Mawlawi, Osama, Davies, Michael A., Vashisht Gopal, Y.N., Di Francesco, M. Emilia, Marszalek, Joseph R., Dewhirst, Mark, Piwnica-Worms, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952969/
https://www.ncbi.nlm.nih.gov/pubmed/31766580
http://dx.doi.org/10.3390/cells8121487

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