A Novel Small Molecule Inhibits Intrahepatocellular Accumulation of Z-Variant Alpha 1-Antitrypsin In Vitro and In Vivo

Alpha 1-antitrypsin deficiency (AATD) is the most common genetic cause of liver disease in children and is associated with early-onset chronic liver disease in adults. AATD associated liver injury is caused by hepatotoxic retention of polymerized mutant alpha 1-antitrypsin molecules within the endop...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaojuan, Pham, Kien, Li, Danmeng, Schutte, Ryan J., Gonzalo, David Hernandez, Zhang, Penghui, Oshins, Regina, Tan, Weihong, Brantly, Mark, Liu, Chen, Ostrov, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953066/
https://www.ncbi.nlm.nih.gov/pubmed/31817705
http://dx.doi.org/10.3390/cells8121586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953066/
https://www.ncbi.nlm.nih.gov/pubmed/31817705
http://dx.doi.org/10.3390/cells8121586

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