Cargando…

Engineering the interactions between a plant‐produced HIV antibody and human Fc receptors

Plants can provide a cost‐effective and scalable technology for production of therapeutic monoclonal antibodies, with the potential for precise engineering of glycosylation. Glycan structures in the antibody Fc region influence binding properties to Fc receptors, which opens opportunities for modula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stelter, Szymon, Paul, Mathew J., Teh, Audrey Y.‐H., Grandits, Melanie, Altmann, Friedrich, Vanier, Jessica, Bardor, Muriel, Castilho, Alexandra, Allen, Rachel Louise, Ma, Julian K‐C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953194/ https://www.ncbi.nlm.nih.gov/pubmed/31301102 http://dx.doi.org/10.1111/pbi.13207

Ejemplares similares

Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants
por: Moore, Catherine M., et al.
Publicado: (2021)

Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum
por: Vanier, Gaëtan, et al.
Publicado: (2015)

Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9
por: Göritzer, Kathrin, et al.
Publicado: (2022)

The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein
por: Suzuki, Takuo, et al.
Publicado: (2021)

Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo
por: Izadi, Shiva, et al.
Publicado: (2021)

Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering
por: Roßkopf, Sophia, et al.
Publicado: (2020)

Engineering of Sialylated Mucin-type O-Glycosylation in Plants
por: Castilho, Alexandra, et al.
Publicado: (2012)

In Planta Glycan Engineering and Functional Activities of IgE Antibodies
por: Montero-Morales, Laura, et al.
Publicado: (2019)

Targeting CD157 in AML using a novel, Fc-engineered antibody construct
por: Krupka, Christina, et al.
Publicado: (2017)

Improving the efficacy of plant-made anti-HIV monoclonal antibodies for clinical use
por: Grandits, Melanie, et al.
Publicado: (2023)

Rational engineering of Fc/Fc receptor interactions to improve antibody potency
por: Doberstein, S, et al.
Publicado: (2003)

The Instability of Dimeric Fc-Fusions Expressed in Plants Can Be Solved by Monomeric Fc Technology
por: Gattinger, Pia, et al.
Publicado: (2021)

Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals
por: Mathieu-Rivet, Elodie, et al.
Publicado: (2014)

Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies
por: van der Horst, Hilma J., et al.
Publicado: (2020)

N-Glycosylation engineering of plants for the biosynthesis of glycoproteins with bisected and branched complex N-glycans
por: Castilho, Alexandra, et al.
Publicado: (2011)

Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life
por: Mackness, Brian C., et al.
Publicado: (2019)

Fc-engineered antibody therapeutics with improved efficacy against COVID-19
por: Yamin, Rachel, et al.
Publicado: (2021)

Editorial: Antibody Fc Engineering: Towards Better Therapeutics
por: Lei, Cheng, et al.
Publicado: (2018)

Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant
por: Mimoto, Futa, et al.
Publicado: (2013)

Distinct Fcα receptor N-glycans modulate the binding affinity to immunoglobulin A (IgA) antibodies
por: Göritzer, Kathrin, et al.
Publicado: (2019)

Investigation of the N-Glycosylation of the SARS-CoV-2 S Protein Contained in VLPs Produced in Nicotiana benthamiana
por: Balieu, Juliette, et al.
Publicado: (2022)

Brassica rapa hairy root based expression system leads to the production of highly homogenous and reproducible profiles of recombinant human alpha‐L‐iduronidase
por: Cardon, Florian, et al.
Publicado: (2018)

B Cell-Based Seamless Engineering of Antibody Fc Domains
por: Hashimoto, Koji, et al.
Publicado: (2016)

Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds
por: Liu, Hongyan, et al.
Publicado: (2017)

IgG Fc engineering to modulate antibody effector functions
por: Wang, Xinhua, et al.
Publicado: (2017)

Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function
por: Escobar-Cabrera, Eric, et al.
Publicado: (2017)

Engineered Fc-glycosylation switch to eliminate antibody effector function
por: Zhou, Qun, et al.
Publicado: (2020)

Fc-engineered antibodies with immune effector functions completely abolished
por: Wilkinson, Ian, et al.
Publicado: (2021)

Fc-Engineered Therapeutic Antibodies: Recent Advances and Future Directions
por: Abdeldaim, Dalia T., et al.
Publicado: (2023)

Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131)
por: Mimoto, F., et al.
Publicado: (2013)

Rapid High Yield Production of Different Glycoforms of Ebola Virus Monoclonal Antibody
por: Castilho, Alexandra, et al.
Publicado: (2011)

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column
por: Kiyoshi, Masato, et al.
Publicado: (2018)

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models
por: Valente, Delphine, et al.
Publicado: (2020)

Significant Impact of Single N-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments
por: Jez, Jakub, et al.
Publicado: (2012)

A general Fc engineering platform for the next generation of antibody therapeutics
por: Chen, Da, et al.
Publicado: (2021)

Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents
por: van Tetering, Geert, et al.
Publicado: (2020)

Fc-Engineering for Modulated Effector Functions—Improving Antibodies for Cancer Treatment
por: Liu, Rena, et al.
Publicado: (2020)

Fc-engineered monoclonal antibodies to reduce off-target liver uptake
por: Mangeat, Tristan, et al.
Publicado: (2023)

An oligosaccharyltransferase from Leishmania major increases the N‐glycan occupancy on recombinant glycoproteins produced in Nicotiana benthamiana
por: Castilho, Alexandra, et al.
Publicado: (2018)

A polymeric immunoglobulin—antigen fusion protein strategy for enhancing vaccine immunogenicity
por: Webster, Gina R., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_745k8q48sdqq0sv30cfokn9pv7