Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens

Gram-negative bacterial infections are a significant public health concern, and the lack of new drug classes for these pathogens is linked to the inability of most drug leads to accumulate inside Gram-negative bacteria(1-7). Here we report the development of a web application, called eNTRyway, which...

Descripción completa

Detalles Bibliográficos
Autores principales: Parker, Erica N., Drown, Bryon S., Geddes, Emily J., Lee, Hyang Yeon, Ismail, Nahed, Lau, Gee W., Hergenrother, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953607/
https://www.ncbi.nlm.nih.gov/pubmed/31740764
http://dx.doi.org/10.1038/s41564-019-0604-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953607/
https://www.ncbi.nlm.nih.gov/pubmed/31740764
http://dx.doi.org/10.1038/s41564-019-0604-5

Ejemplares similares