Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation

BACKGROUND: While all clinically translated antibody-drug conjugates (ADCs) contain a single-drug payload, most systemic cancer chemotherapies involve use of a combination of drugs. These regimens improve treatment outcomes and slow development of drug resistance. We here report the generation of an...

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Detalles Bibliográficos
Autores principales: Nilchan, Napon, Li, Xiuling, Pedzisa, Lee, Nanna, Alex R, Roush, William R, Rader, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953743/
https://www.ncbi.nlm.nih.gov/pubmed/31930187
http://dx.doi.org/10.1093/abt/tbz009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953743/
https://www.ncbi.nlm.nih.gov/pubmed/31930187
http://dx.doi.org/10.1093/abt/tbz009

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