Cargando…

Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo

PURPOSE: To test the hypothesis that imaging biomarkers are useful for evaluating in vivo rod photoreceptor cell responses to a mitochondrial protonophore. METHODS: Intraperitoneal injections of either the mitochondrial uncoupler 2,4 dinitrophenol (DNP) or saline were given to mice with either highe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berkowitz, Bruce A., Olds, Hailey K., Richards, Collin, Joy, Joydip, Rosales, Tilman, Podolsky, Robert H., Childers, Karen Lins, Hubbard, W. Brad, Sullivan, Patrick G., Gao, Shasha, Li, Yichao, Qian, Haohua, Roberts, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953833/ https://www.ncbi.nlm.nih.gov/pubmed/31923239 http://dx.doi.org/10.1371/journal.pone.0226840

Ejemplares similares

Functional regulation of an outer retina hyporeflective band on optical coherence tomography images
por: Gao, Shasha, et al.
Publicado: (2021)

Author Correction: Functional regulation of an outer retina hyporeflective band on optical coherence tomography images
por: Gao, Shasha, et al.
Publicado: (2022)

Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice
por: Berkowitz, Bruce A., et al.
Publicado: (2021)

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT
por: Berkowitz, Bruce A., et al.
Publicado: (2019)

Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo
por: Berkowitz, Bruce A., et al.
Publicado: (2018)

Correcting QUEST Magnetic Resonance Imaging–Sensitive Free Radical Production in the Outer Retina In Vivo Does Not Correct Reduced Visual Performance in 24-Month-Old C57BL/6J Mice
por: Berkowitz, Bruce A., et al.
Publicado: (2021)

THE RESPIRATION OF THE ISOLATED ROD OUTER LIMB OF THE FROG RETINA
por: Hubbard, Ruth
Publicado: (1954)

Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study
por: Berkowitz, Bruce A., et al.
Publicado: (2022)

Rod and Cone Coupling Modulates Photopic ERG Responses in the Mouse Retina
por: Li, Yichao, et al.
Publicado: (2020)

Rod Photoreceptor Neuroprotection in Dark-Reared Pde6brd10 Mice
por: Berkowitz, Bruce A., et al.
Publicado: (2020)

Mitochondrial Dysfunction After Repeated Mild Blast Traumatic Brain Injury Is Attenuated by a Mild Mitochondrial Uncoupling Prodrug
por: Hubbard, W. Brad, et al.
Publicado: (2023)

Light-Dependent OCT Structure Changes in Photoreceptor Degenerative rd 10 Mouse Retina
por: Li, Yichao, et al.
Publicado: (2018)

Tight Junctions of the Outer Blood Retina Barrier
por: Naylor, Aisling, et al.
Publicado: (2019)

Light-Induced Thickening of Photoreceptor Outer Segment Layer Detected by Ultra-High Resolution OCT Imaging
por: Li, Yichao, et al.
Publicado: (2016)

Microglia in Cultured Porcine Retina: Qualitative Immunohistochemical Analyses of Reactive Microglia in the Outer Retina
por: Johansson, Kjell, et al.
Publicado: (2023)

Using Stem Cells to Model Diseases of the Outer Retina
por: Yvon, Camille, et al.
Publicado: (2015)

Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration
por: Kim, Benjamin J., et al.
Publicado: (2019)

Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers
por: Berkowitz, Bruce A., et al.
Publicado: (2022)

Do multiple physiological OCT biomarkers indicate age-related decline in rod mitochondrial function in C57BL/6J mice?
por: Goodman, Cole, et al.
Publicado: (2023)

KINETICS OF ROD OUTER SEGMENT RENEWAL IN THE DEVELOPING MOUSE RETINA
por: LaVail, Matthew M.
Publicado: (1973)

Assembly of the outer retina in the absence of GABA synthesis in horizontal cells
por: Schubert, Timm, et al.
Publicado: (2010)

Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
por: Parravano, M., et al.
Publicado: (2021)

Data-Driven Models of Efficient Chromatic Coding in the Outer Retina
por: Ramirez, Luisa, et al.
Publicado: (2022)

3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina
por: Keeling, Eloise, et al.
Publicado: (2020)

Multiple Bioenergy-Linked OCT Biomarkers Suggest Greater-Than-Normal Rod Mitochondria Activity Early in Experimental Alzheimer's Disease
por: Berkowitz, Bruce A., et al.
Publicado: (2023)

Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina
por: Joselevitch, Christina, et al.
Publicado: (2007)

Defects in the Outer Limiting Membrane Are Associated with Rosette Development in the Nrl(−/−) Retina
por: Stuck, Michael W., et al.
Publicado: (2012)

Synaptic remodeling generates synchronous oscillations in the degenerated outer mouse retina
por: Haq, Wadood, et al.
Publicado: (2014)

Recovery of outer retina in acute idiopathic blind spot enlargement (AIBSE)
por: Trese, Matthew G.J., et al.
Publicado: (2016)

Outer retina changes on optical coherence tomography in vitamin A deficiency
por: Berkenstock, Meghan K., et al.
Publicado: (2020)

Neurofascin Is a Novel Component of Rod Photoreceptor Synapses in the Outer Retina
por: Pourhoseini, Sahar, et al.
Publicado: (2021)

Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes
por: Hu, Jane, et al.
Publicado: (2020)

Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice
por: Morrow, Eric M, et al.
Publicado: (2005)

Correlation of Optical Coherence Tomography and Autofluorescence in the Outer Retina and Choroid of Patients With Choroideremia
por: Xue, Kanmin, et al.
Publicado: (2016)

C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina
por: Burger, Courtney A., et al.
Publicado: (2020)

Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis
por: Ziccardi, Lucia, et al.
Publicado: (2020)

Apical CLC‐2 in retinal pigment epithelium is crucial for survival of the outer retina
por: Hanke‐Gogokhia, Christin, et al.
Publicado: (2021)

Commentary on “Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes”
por: Dhooge, Patty P.A., et al.
Publicado: (2021)

Correlation between Choroidal Vascularity Index and Outer Retina in Patients with Diabetic Retinopathy
por: Sidorczuk, Patryk, et al.
Publicado: (2022)

Phase-sensitive imaging of the outer retina using optical coherence tomography and adaptive optics
por: Jonnal, Ravi S., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_05b991tnbl1jbqbmdi6hmhgn6e