C-mannosylation supports folding and enhances stability of thrombospondin repeats

Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1 repeats (TSRs) of netrin receptor UNC-5. In absence of C-mannosylation, UNC-...

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Detalles Bibliográficos
Autores principales: Shcherbakova, Aleksandra, Preller, Matthias, Taft, Manuel H, Pujols, Jordi, Ventura, Salvador, Tiemann, Birgit, Buettner, Falk FR, Bakker, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954052/
https://www.ncbi.nlm.nih.gov/pubmed/31868591
http://dx.doi.org/10.7554/eLife.52978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954052/
https://www.ncbi.nlm.nih.gov/pubmed/31868591
http://dx.doi.org/10.7554/eLife.52978

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