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C-mannosylation supports folding and enhances stability of thrombospondin repeats
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1 repeats (TSRs) of netrin receptor UNC-5. In absence of C-mannosylation, UNC-...
Autores principales: | Shcherbakova, Aleksandra, Preller, Matthias, Taft, Manuel H, Pujols, Jordi, Ventura, Salvador, Tiemann, Birgit, Buettner, Falk FR, Bakker, Hans |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954052/ https://www.ncbi.nlm.nih.gov/pubmed/31868591 http://dx.doi.org/10.7554/eLife.52978 |
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