Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure

Mitochondrial creatine kinase (Mt-CK) is a major determinant of cardiac energetic status and is down-regulated in chronic heart failure, which may contribute to disease progression. We hypothesised that cardiomyocyte-specific overexpression of Mt-CK would mitigate against these changes and thereby p...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Fang, Maguire, Mahon L., McAndrew, Debra J., Lake, Hannah A., Neubauer, Stefan, Zervou, Sevasti, Schneider, Jürgen E., Lygate, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954138/
https://www.ncbi.nlm.nih.gov/pubmed/31925563
http://dx.doi.org/10.1007/s00395-020-0777-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954138/
https://www.ncbi.nlm.nih.gov/pubmed/31925563
http://dx.doi.org/10.1007/s00395-020-0777-3

Ejemplares similares