Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly understood. Here we perform TCRB sequencing, inte...

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Detalles Bibliográficos
Autores principales: Sheih, Alyssa, Voillet, Valentin, Hanafi, Laïla-Aïcha, DeBerg, Hannah A., Yajima, Masanao, Hawkins, Reed, Gersuk, Vivian, Riddell, Stanley R., Maloney, David G., Wohlfahrt, Martin E., Pande, Dnyanada, Enstrom, Mark R., Kiem, Hans-Peter, Adair, Jennifer E., Gottardo, Raphaël, Linsley, Peter S., Turtle, Cameron J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954177/
https://www.ncbi.nlm.nih.gov/pubmed/31924795
http://dx.doi.org/10.1038/s41467-019-13880-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954177/
https://www.ncbi.nlm.nih.gov/pubmed/31924795
http://dx.doi.org/10.1038/s41467-019-13880-1

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