Structures of β-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition

LXYL-P1-2 is one of the few xylosidases that efficiently catalyze the reaction from 7-β-xylosyl-10-deacetyltaxol (XDT) to 10-deacetyltaxol (DT), and is a potential enzyme used in Taxol industrial production. Here we report the crystal structure of LXYL-P1-2 and its XDT binding complex. These structu...

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Detalles Bibliográficos
Autores principales: Yang, Lin, Chen, Tian-Jiao, Wang, Fen, Li, Li, Yu, Wen-Bo, Si, Yi-Kang, Chen, Jing-Jing, Liu, Wan-Cang, Zhu, Ping, Gong, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954215/
https://www.ncbi.nlm.nih.gov/pubmed/31925310
http://dx.doi.org/10.1038/s42003-019-0744-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954215/
https://www.ncbi.nlm.nih.gov/pubmed/31925310
http://dx.doi.org/10.1038/s42003-019-0744-4

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