PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1(KO)) reduces muscle mass. PHD1(KO) muscles show impaired mTORC1 activation in respons...

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Detalles Bibliográficos
Autores principales: D’Hulst, Gommaar, Soro-Arnaiz, Inés, Masschelein, Evi, Veys, Koen, Fitzgerald, Gillian, Smeuninx, Benoit, Kim, Sunghoon, Deldicque, Louise, Blaauw, Bert, Carmeliet, Peter, Breen, Leigh, Koivunen, Peppi, Zhao, Shi-Min, De Bock, Katrien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954236/
https://www.ncbi.nlm.nih.gov/pubmed/31924757
http://dx.doi.org/10.1038/s41467-019-13889-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954236/
https://www.ncbi.nlm.nih.gov/pubmed/31924757
http://dx.doi.org/10.1038/s41467-019-13889-6

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