Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.

Gene expression can be activated or suppressed using CRISPR/Cas9 systems. However, tools that enable dose-dependent activation of gene expression without the use of exogenous transcription regulatory proteins are lacking. Here we describe chemical epigenetic modifiers (CEMs) designed to activate the...

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Detalles Bibliográficos
Autores principales: Chiarella, Anna M., Butler, Kyle V., Gryder, Berkley E., Lu, Dongbo, Wang, Tiffany A., Yu, Xufen, Pomella, Silvia, Khan, Javed, Jin, Jian, Hathaway, Nathaniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954327/
https://www.ncbi.nlm.nih.gov/pubmed/31712774
http://dx.doi.org/10.1038/s41587-019-0296-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954327/
https://www.ncbi.nlm.nih.gov/pubmed/31712774
http://dx.doi.org/10.1038/s41587-019-0296-7

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