Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells

Transcriptional networks supervising class IIa HDAC expression are poorly defined. Here we demonstrate that MEF2D is the key factor controlling HDAC9 transcription. This control, which is part of a negative feed-back loop during muscle differentiation, is hijacked in cancer. In leiomyosarcomas the M...

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Detalles Bibliográficos
Autores principales: Di Giorgio, Eros, Dalla, Emiliano, Franforte, Elisa, Paluvai, Harikrishnareddy, Minisini, Martina, Trevisanut, Matteo, Picco, Raffaella, Brancolini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954409/
https://www.ncbi.nlm.nih.gov/pubmed/31754707
http://dx.doi.org/10.1093/nar/gkz1120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954409/
https://www.ncbi.nlm.nih.gov/pubmed/31754707
http://dx.doi.org/10.1093/nar/gkz1120

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