Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity

Mitochondrial DNA (mtDNA) resides in a high ROS environment and suffers more mutations than its nuclear counterpart. Increasing evidence suggests that mtDNA mutations are not the results of direct oxidative damage, rather are caused, at least in part, by DNA replication errors. To understand how the...

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Detalles Bibliográficos
Autores principales: Anderson, Andrew P, Luo, Xuemei, Russell, William, Yin, Y Whitney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954441/
https://www.ncbi.nlm.nih.gov/pubmed/31799610
http://dx.doi.org/10.1093/nar/gkz1018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954441/
https://www.ncbi.nlm.nih.gov/pubmed/31799610
http://dx.doi.org/10.1093/nar/gkz1018

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