Cargando…

Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

BACKGROUND: Ovarian cancer is one of the most common and malignant cancers, partly due to its late diagnosis and high recurrence. Chemotherapy resistance has been linked to poor prognosis and is believed to be linked to the cancer stem cell (CSC) pool. Therefore, elucidating the molecular mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muñoz-Galván, Sandra, Felipe-Abrio, Blanca, Verdugo-Sivianes, Eva M., Perez, Marco, Jiménez-García, Manuel P., Suarez-Martinez, Elisa, Estevez-Garcia, Purificacion, Carnero, Amancio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954568/ https://www.ncbi.nlm.nih.gov/pubmed/31926547 http://dx.doi.org/10.1186/s12943-020-1130-z

Ejemplares similares

c‐MYB‐ and PGC1a‐dependent metabolic switch induced by MYBBP1A loss in renal cancer
por: Felipe‐Abrio, Blanca, et al.
Publicado: (2019)

Loss of MYBBP1A Induces Cancer Stem Cell Activity in Renal Cancer
por: Felipe-Abrio, Blanca, et al.
Publicado: (2019)

New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
por: Muñoz-Galván, Sandra, et al.
Publicado: (2019)

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
por: García-Heredia, José M., et al.
Publicado: (2016)

Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer
por: Verdugo-Sivianes, Eva M., et al.
Publicado: (2017)

The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness
por: Felipe-Abrio, Blanca, et al.
Publicado: (2020)

Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle
por: Verdugo-Sivianes, Eva M., et al.
Publicado: (2021)

Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment
por: Perez, Marco, et al.
Publicado: (2020)

Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells
por: Verdugo-Sivianes, Eva M, et al.
Publicado: (2021)

MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy
por: Rivero, Maria, et al.
Publicado: (2018)

Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer
por: Muñoz-Galván, Sandra, et al.
Publicado: (2020)

Leveraging Genomics, Transcriptomics, and Epigenomics to Understand the Biology and Chemoresistance of Ovarian Cancer
por: Muñoz-Galván, Sandra, et al.
Publicado: (2021)

Chronotherapy: Circadian Rhythms and Their Influence in Cancer Therapy
por: Amiama-Roig, Ana, et al.
Publicado: (2022)

A Six-Gene Prognostic and Predictive Radiotherapy-Based Signature for Early and Locally Advanced Stages in Non-Small-Cell Lung Cancer
por: Peinado-Serrano, Javier, et al.
Publicado: (2022)

Implications of maraviroc and/or rapamycin in a mouse model of fragility
por: Pérez-Martínez, Laura, et al.
Publicado: (2020)

A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules
por: García-Heredia, José Manuel, et al.
Publicado: (2023)

Cellular Senescence as a Target in Cancer Control
por: Vergel, Mar, et al.
Publicado: (2010)

MAP17 and SGLT1 Protein Expression Levels as Prognostic Markers for Cervical Tumor Patient Survival
por: Perez, Marco, et al.
Publicado: (2013)

Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA
por: Perez, Marco, et al.
Publicado: (2015)

Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1
por: Lubomirov, Lubomir T., et al.
Publicado: (2019)

NAD pool as an antitumor target against cancer stem cells in head and neck cancer
por: Navas, Lola E., et al.
Publicado: (2023)

Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1)
por: Perez, Marco, et al.
Publicado: (2016)

PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome
por: Estevez-Garcia, Purificacion, et al.
Publicado: (2012)

MYPT1 reduction is a pathogenic factor of erectile dysfunction
por: Zhao, Wei, et al.
Publicado: (2022)

Should We Expect an Increase in the Number of Cancer Cases in People with Long COVID?
por: Amiama-Roig, Ana, et al.
Publicado: (2023)

MYPT1 Protein Isoforms Are Differentially Phosphorylated by Protein Kinase G
por: Yuen, Samantha, et al.
Publicado: (2011)

Synthetic VSMCs induce BBB disruption mediated by MYPT1 in ischemic stroke
por: Meng, Hailan, et al.
Publicado: (2021)

Identification of the Kinase-Substrate Recognition Interface between MYPT1 and Rho-Kinase
por: Amano, Mutsuki, et al.
Publicado: (2022)

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
por: Xiao, Lan, et al.
Publicado: (2021)

Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells
por: García-Heredia, José Manuel, et al.
Publicado: (2020)

High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer
por: Lopez-Guerra, Jose Luis, et al.
Publicado: (2015)

The role of Hippo pathway in ovarian development
por: Zhu, Mengdi, et al.
Publicado: (2023)

Downregulation of vimentin expression increased drug resistance in ovarian cancer cells
por: Huo, Yi, et al.
Publicado: (2016)

Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer
por: Estevez-Garcia, Purificacion, et al.
Publicado: (2015)

Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain
por: Garcia-Heredia, Jose M., et al.
Publicado: (2015)

Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases
por: García-Heredia, José M., et al.
Publicado: (2018)

The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
por: García-Heredia, José M., et al.
Publicado: (2017)

NUMB and NUMBL differences in gene regulation
por: García-Heredia, José Manuel, et al.
Publicado: (2018)

Role of Mitochondria in Cancer Stem Cell Resistance
por: García-Heredia, José Manuel, et al.
Publicado: (2020)

Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness
por: Espinosa-Sánchez, Asunción, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0iq4ma21k6d9ug2q91tjv3pm6i