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DECENT: differential expression with capture efficiency adjustmeNT for single-cell RNA-seq data

MOTIVATION: Dropout is a common phenomenon in single-cell RNA-seq (scRNA-seq) data, and when left unaddressed it affects the validity of the statistical analyses. Despite this, few current methods for differential expression (DE) analysis of scRNA-seq data explicitly model the process that gives ris...

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Detalles Bibliográficos
Autores principales: Ye, Chengzhong, Speed, Terence P, Salim, Agus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954660/
https://www.ncbi.nlm.nih.gov/pubmed/31197307
http://dx.doi.org/10.1093/bioinformatics/btz453