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Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments
Many enzymes assemble into defined oligomers, providing a mechanism for cooperatively regulating activity. Recent studies have described a mode of regulation in which enzyme activity is modulated by polymerization into large-scale filaments. Here we describe an ultrasensitive form of polymerization-...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954954/ https://www.ncbi.nlm.nih.gov/pubmed/31873303 http://dx.doi.org/10.1038/s41594-019-0352-5 |