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The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C

Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRIP1 form a protein complex in the brain, and co-ope...

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Detalles Bibliográficos
Autores principales: Twelvetrees, Alison E., Lesept, Flavie, Holzbaur, Erika L. F., Kittler, Josef T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955223/
https://www.ncbi.nlm.nih.gov/pubmed/31757889
http://dx.doi.org/10.1242/jcs.215822